Challenge analysis limitations and break through separation bottlenecks!

On November 18, 2024, Acchrom-Tech launched the AlphaHybrid C18 hybrid silica gel chromatography column at the 12th Munich Shanghai Analytical Biochemistry Exhibition.
The AlphaHybrid C18 hybrid silica gel chromatography column adopts self-developed organic-inorganic hybrid silica gel based spheres and surface bonding technology, bringing you a brand new chromatographic analysis experience!

AlphaHybrid C18, Not just 'alkali resistance'!

Performance Display

In the accelerated pH stability test, AlphaHybrid C18 maintained a column efficiency of over 80% after 300 hours under the conditions of 50mM triethylamine (pH=10) and column temperature of 50 ℃.

(Peaks 1_uracil; Peaks 2-propranolol; Peaks 3-naphthalene; Peaks 4-phenanthrene; Peaks 5-amitriptyline)

Improve the flexibility of method development

The range of pH 2-12 is suitable for various analysis methods and conditions, and users can flexibly adjust according to experimental needs to meet the analysis needs of different samples. For example, in the analysis of caffeine and its metabolites, when the pH is in the low to medium stage, xanthine and theophylline are difficult to separate due to their similarity, while when the pH reaches 10, the two can be clearly distinguished.

(Peak 1: Uracil; Peak 2: Procaine (pKa=8.7); Peak 3_ Non Caolong; Peak 4_ p-nitrobenzoic acid (pKa=3.4)

(Peak 1: Uracil; Peak 2: Procaine (pKa=8.7); Peak 3_ Non Caolong; Peak 4_ p-nitrobenzoic acid (pKa=3.4)

Durable and long-lasting, with high cost-effectiveness

The high-performance hybrid particles and optimized structural design make AlphaHybrid C18 have outstanding durability. After continuous injection of 1000 needles, the retention time and theoretical plate number of procaine and lidocaine are almost maintained at the initial state, indicating that AlphaHybrid C18 can maintain stable separation effect for a long time and bring higher cost-effectiveness to users.

Ultra low silanol based activity

The hybrid silica gel chromatography column reduces the number of silanol groups during the synthesis process, thereby reducing its acidity and ion exchange with alkaline compounds. Based on the analysis results of five alkaline compounds, AlphaHybrid C18 improves the peak shape and separation efficiency of alkaline compounds.

(Peak 1_desipramine; Peak 1_demethylamine; Peak 3_ doxepin; Peak 4_ imipramine; Peak 5_ amitriptyline)

Reliable inter batch reproducibility

A precise and rigorous product control and management system ensures that each batch of fillers meets consistency standards, ensuring the continuous reliability and accuracy of data throughout the entire lifecycle of analytical methods.

Application Cases   Chemical medicine   β - receptor blockers

Clozapine and its impurities

(Peak 1_Clozapine Impurity A; Peak D_Clozapine Impurity D; Peak 3_Cclozapine Impurity C; Peak 4_Cclozapine; Peak 5_Cclozapine Impurity B;)

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